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KMID : 0613319970030020080
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Journal of the Korean Bone and Joint Tumor Soceity
1997 Volume.3 No. 2 p.80 ~ p.89
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Regeneration of Low-Heat-Treated Sciatic Nerve of Rabbit
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Kim Jae-Do
kim Sang-Jin
Jung Cheoul-Yun
Hong Young-Gi
Kim Ghi-Chan
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Abstract
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Maligeant tumors of extremeties involving major neurovascular structures have been treated by amputation. However recent developent of diagnostic tools[CT, MRI etc.], surgical techniques, anticancer chemotherapeutic agents, and radiation techniques allow surgeons to treat malignant tumors in the limb without amputation. It has been reported that a local application of low-heat to the tissue with tumor can kill tumor cells. It is, however, not known if the attendant neural and vascular injuries may be recovered. The present study was, therfore, undertakn to address this question in rabbit sciatic nerves. A low-heat injury to the sciatic nerve was induced by perfusing the nerve with 60 saline for 30 minutes and the courses of functional and morphological recovery of the nerve were evaluated for 16 weeks. The results are summerized as follows : 1. In the electromyographic nerve conduction test the average amplitude was markedly attenuated at 4 and 8 weeks after the low-heat treatment, but it progressively increased to the level 89.5% of the control at 16 week post-treatment. The average latency in the control group was 0.62 msec. The latency in the experimental
group was much longer than this at 4 and 8 week post-treatment, but it progressively reverted to the control level, showing 0.622 msec at 16 weeks. 2. In the needle EMG, many fibrillation potentials and positive sharp waves were appeared until 8 weeks post-treatment. After 16 weeks,however, no fibrillation potential was observed. 3. In the early phase of post-treatment period, the myelinated nerve fivers contained many vacuoles and the number of myelinated nerve fibers appeared to be consederably reduced. Howecer, as time goes myelinated nerve fibers were regenerated, such that affter 16 weeks the histologic appearance of the nerve was similar to that of rhe control group.
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KEYWORD
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Low-heat injury, Sciatic nerve, Regeneration
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